Study of the mutation causing type 1 polysaccharide storage myopathy in a Mangalarga Marchador population used in breeding programs

The Mangalarga Marchador (MM) breed, which originated in Brazil, constitutes the largest number of horses country. animals are versatile and used several sports because major investments made for genetic improve-ment breed. In recent decades, advances molecular techniques enabled identification diseases hor-ses. Conducting tests determining occurrence mutations fundamental early prevention abnormalities. Among known that occur horses, c.926G>A mutation GYS1gene causes type 1 polysaccharide storage myopathy (PSSM1) stands out, it has been identified breeds horses. Although is common MM GYS1 gene not yet evaluated. lack knowledge about possible presence PSSM1 averts adoption control measures to prevent spread disease Therefore, aim this study was verify muta-tion breeding programs. Blood DNA extracted region containing amplified sequenced. No found evaluated sam-ples. However, since clinical signs frequently observed further studies, including histological analysis, necessary establish underlying causes. addition, if there a pattern occurrence, studies should be considered.